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DIM 100mg 120 tabs
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MSRP: $39.98
Price: $21.79
Manufacturer: Source Naturals
Manufacturer Part No: 2107801567
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DIM is an indole phytochemical that is a natural metabolite of
compounds found in cruciferous vegetables such as broccoli, Brussels
sprouts and cabbage. In animal and in-vitro studies, DIM has
been shown to lead to the preferential formation of estrogen
metabolites that are correlated with healthy breast, endometrial, and
cervical tissues. This unique property sets DIM apart from other plant
nutrients. Source Naturals DIM is combined with phospholipids, vitamin E and bioperine for enhanced absorption.
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Supplement Facts for 100 mg Tablet
Serving Size: 1 Tablet
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Amount
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%DV
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| Vitamin E (as D-alpha tocopheryl)
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50 IU
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167%
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| Diindolylmethane (DIM)
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100 mg
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†
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| Phosphatidyl Choline
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25 mg
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†
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| Pepper Fruit Extract (Bioperine®)
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3 mg
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†
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Other Ingredients: microcrystalline cellulose, magnesium stearate, colloidal silicon dioxide, and stearic acid.
Suitable for vegetarians.
Contains soy.
Warning: Do
not take this product if you are pregnant, may become pregnant, or
breastfeeding, or are taking immunosuppressive therapies.
Do not use if either tamper-evident seal is broken or missing. Keep out of the reach of children.
Suggested Use: 1 to 4 tablets daily with meals.
The Importance of Healthy Estrogen Metabolism in Men's Health
In
men, there is a new appreciation of the effects of changing estrogen
metabolism with aging, now identified as "andropause". German
researchers have clearly documented a dramatic, aging-related
accumulation of estrogen in human prostate glands.58
This work correlated age, estrogen accumulation, and the presence of
benign prostatic hypertrophy. This underscores the role of estrogen as
a growth promoting hormone in men as well as women. Tissue accumulation
of estrogen is a unique hallmark of andropause, distinct from estrogen
deficiency which characterizes menopause. Recent work shows that
estradiol, the active form of estrogen, provokes increases in prostate
specific antigen (PSA) production in human prostate tissue.59
This increase in PSA is as great as that seen with testosterone.
Increased PSA production was specifically inhibited by
2-methoxyestradiol, the beneficial estrogen metabolite whose production
is promoted by DIM. 59
Accumulation of estrogen during andropause is amplified by obesity60
since fat tissue is the site of conversion of both testosterone and
DHEA into estrogen. In case control studies, higher levels of
circulating estrogen predict the degree of prostate enlargement. More
importantly, increased estrogen levels have been repeatedly noted as a
risk factor for early atherosclerosis and heart attack.61,62,63 The risks of elevated estrogen in men further correlate to decreased ability to dissolve blood clots.64
The specific deficiency in men of an active, beneficial metabolism of
estrogen leading to 2-methoxy estrogens would explain many, if not all,
of these observations.
Recent experimental work supports
this connection between healthy estrogen metabolism and men's health.
In studies culturing human vascular endothelial cells (HUVEC), it has
been shown that 2-methoxy estradiol is a primary regulator of cell
growth and apoptosis.65
Active and regulated apoptosis may contribute to the prevention of
atherosclerotic plaque formation. At the basic level of lipoprotein
status, 2-hydroxy and 2-methoxy estrogens are powerful antioxidants. In
recent experiments, these metabolites, whose production is promoted by
DIM, have been shown to prevent the oxidation of human lipoproteins.66 Lipoprotein oxidation is now accepted as an early, initiating event in atherosclerosis.
While it remains to be demonstrated through intervention studies that
DIM supplementation can slow the progression of prostate disease and
atherosclerosis, it is clear that DIM supplementation in men can
beneficially shift estrogen metabolism. The supplemental use of DHEA
has been advocated in men to replace dramatically decreased DHEA
production with aging. A primary concern regarding this use of DHEA has
been its partial conversion into estrogen. By promoting a healthy
estrogen metabolism, use of DIM by men will increase the safety and
benefits of long term supplementation with DHEA.
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